By Horace W. Davenport
This ebook examines the historical past of experimental learn in gastric secretion and digestion. the writer identifies the clinical questions that experience occupied researchers and discusses the experiments that experience ended in their strategies. by means of setting apart facets of experimental examine and tracing their evolution through the years, the e-book offers gastric physiologists and gastroenterologists with an outstanding knowing of the highbrow historical past in their box.
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Extra info for A History of Gastric Secretion and Digestion: Experimental Studies to 1975
That accounts for the fact that when Nencki and Shumova-Simanovskaya fed their dogs sodium iodidein doses of2 to 4 g, they found that the iodide concentration in gastricjuice did not exceed 2 mN. 83 Their data did not show a relation between plasma and gastric juice concentrations. A relationwas crudely demonstrated by Werner Lipschitz ofFrankfurt in 1929 when he injected sodium iodide intravenously into dogs with Pavlov pouches. Lipschitz's data show that soon after injection when the blood concentration of iodide was high, the ratio of iodide in gastric juice to iodide in blood was in the range of 2 to 4, whereas when the blood iodide concentration fell, the ratio could be as high as 18.
E. Mason and H. S. w ... 2 3 4 5 • 7 \< • ........ ·--·-· ~--~·---:---~-- "",. _r:.. · . ,. ·.. :.. e• 3 4 _: 2 3 4 5 6 7 ·?! 11 J .. 4 5 _,F'"· . I II 7 c Figure 1-15. A: Ordinates, ratio of the concentration of iodide in gastric juicetothat in plasma. Abscissae, plasma iodide concentration in millimoles per Iiter. B: Ordinates, gastric juice iodide cci_ncentration in millimoles per Iiter. Abscissae, plasma iodide concentration in millimöles per Iiter. C: Ordinates, ratio of iodide concentration in plasma tothat in gastric juice.
Carbonic Anhydrase in Parietal Cells My demonstration in 1938-39 that carbonic anhydrase is present in high concentration in parietal cells is important, not because it permitted speculation that hydration of carbon dioxide is the source of secreted hydrogen ions, but because it was the first fragment of evidence concerning the biochemical constitution of the cells. When N. U. Meldrum and F. J. W. Roughton found carbonic anhydrase in erythrocytes, they failed to find it in the starnach for reasons that have nothing to do with Iabaratory work.