An Intraoperative Beta−Probe for Cancer Surgery by Francesco Collamati

By Francesco Collamati

This thesis makes a speciality of a singular radio-guided surgical procedure approach for entire tumor resections. It describes all points of the intraoperative probe, in addition to checking out and simulation of the radical process. The presentation develops the procedure from the preliminary concept to real looking feasibility reports which have been the topic of a statement of the yank Society of Nuclear drugs. only a 12 months after finishing this paintings, the procedure has now been confirmed for the 1st time on a meningioma sufferer, confirming the entire predictions made during this thesis.

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2 SwThr/HwThr Fig. 16 Extraction of the conversion factor between “software threshold” and “hardware threshold”, as explained in Sect. 2, for Probe1 (top), Probe4 (center) and ProbeSiPm (bottom). In the first two cases the fit was performed only over a certain hardware threshold below which the electronic noise is dominant. 3 Probes Optimization and Development 45 detector, regarding the characteristics of the active material (chemical and mechanical), the shielding and the readout system. 1 Spectrophotomery As seen in Sect.

The light emitted from the lamp was carried by an optical fiber to the front face of the investigated sample, housed in a devoted support. Another optical fiber, placed on the opposite side of the sample carries the transmitted light to the Spectrophometer. The obtained spectrum is showed in Fig. 17, together with the one in absence of the sample, to show the spectral components of the used UV lights. e. the edge of visible light, which is a zone commonly well covered by standard PMT, and also by the one used in the first prototypes.

1 Physics in FLUKA The strength of FLUKA is in its physical models: microscopic models are adopted whenever possible, consistency among all the reaction steps and/or reaction types is ensured, conservation laws are enforced at each step, and crosschecks between results and experimental data are done at single interaction level. As a result, final predictions are obtained with a minimal set of free parameters fixed for all energy, target and projectile combinations. Therefore results in complex cases, as well as properties and scaling laws, arise naturally from the underlying physical models, predictivity is provided where no experimental data are directly available, and correlations within interactions and among eventual shower components are preserved.

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