Autophagy by Daniel J. Klionsky

By Daniel J. Klionsky

Klionsky (life sciences, U. of Michigan, Ann Arbor) defines "autophagy" as "a procedure during which the mobile normally undergoes membrane rearrangement to sequester a component of cytoplasm, convey it to a degradative organelle and recycle the macromolecular parts. He argues that, within the conventional view of organelles as mobile rubbish disposals, the continuing force towards homeostatis among phone demise and synthesis has been neglected. His advent additionally lists the hot nomenclature for 27 autophagy-related genes. In 22 different chapters, foreign members overview autophagy in organisms from yeast to people and its roles in metabolism, getting older, melanoma and neuromuscular illnesses. a few photographs are in colour.

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96. Tanaka Y, Guhde G, Suter A et al. Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice. Nature 2000; 406:902-906. 97. Suriapranata I, Epple UD, Bernreuther D et al. The breakdown of autophagic vesicles inside the vacuole depends on Aut4p. J Cell Sci 2000; 113:4025-4033. 98. Epple UD, Suriapranata I, Eskelinen E-L et al. Aut5/Cvt17p, a putative lipase essential for disintegration of autophagic bodies inside the vacuole. J Bacteriol 2001; 183:5942-5955. 99. Teter SA, Eggerton KP, Scott SV et al.

Yeast Mon1p/Aut12p functions in vacuolar fusion of autophagosomes and cvt-vesicles. FEBS Lett 2002; 530:174-180. 94. Meiling-Wesse K, Barth H, Thumm M. Ccz1p/Aut11p/Cvt16p is essential for autophagy and the cvt pathway. FEBS Lett 2002; 526:71-76. 95. Wang C-W, Stromhaug PE, Shima J et al. The Ccz1-Mon1 protein complex is required for the late step of multiple vacuole delivery pathways. J Biol Chem 2002; 277:47917-47927. 96. Tanaka Y, Guhde G, Suter A et al. Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice.

Virchows Arch B Cell Pathol 1990; 58:189-197. 93. Meiling-Wesse K, Barth H, Voss C et al. Yeast Mon1p/Aut12p functions in vacuolar fusion of autophagosomes and cvt-vesicles. FEBS Lett 2002; 530:174-180. 94. Meiling-Wesse K, Barth H, Thumm M. Ccz1p/Aut11p/Cvt16p is essential for autophagy and the cvt pathway. FEBS Lett 2002; 526:71-76. 95. Wang C-W, Stromhaug PE, Shima J et al. The Ccz1-Mon1 protein complex is required for the late step of multiple vacuole delivery pathways. J Biol Chem 2002; 277:47917-47927.

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