By Herman Friedman, Yoshimasa Yamamoto, Mauro Bendinelli
Chlamydia pneumoniae is a micro organism that's most typically identified for inflicting colds and pneumonia. although, researchers have lately came across a hyperlink among C. pneumoniae and atherosclerosis, a clogging of the arteries that motives middle assault and stroke. additionally, ongoing examine is displaying that sure traces may possibly play a task in bronchial asthma, a number of sclerosis, Alzheimer's sickness, and arthritis.
This quantity, a part of the Infectious brokers and Pathogenesis sequence, is a whole portrait of C. pneumoniae and what's at present recognized approximately it.
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Extra resources for Chlamydia pneumoniae: infection and disease
Electron microscopic images of the in vitro developmental prospect are presented in Fig. 2. The initial events in the C. pneumoniae infection are the attachment of the EB to the host cell by electrostatic interaction, and successive association of the EB to the host cell receptor, followed by internalization into the host cytoplasm by induction of active phagocytosis. The phagocytic vesicle containing the EB migrates toward the Golgi area. In in vivo C. pneumoniae infection, the EB exhibit affinity for epithelial cells of the mucosal membrane in the respiratory tract.
37. , Pogson, C. , Jones, M. , and Pearce, J. , 2000, Chlamydial development is adversely affected by minor changes in amino acid supply, blood plasma amino acid levels, and glucose deprivation, Infect. Immun. 68:1457–1464. 38. Pantoja, L. , Miller, R. , Ramirez, J. , Molestina, R. , and Summersgill, J. , 2001, Characterization of Chlamydia pneumoniae persistence in HEp-2 cells treated with gamma interferon, Infect. Immun. 69:7927–7932. 39. , 2001, Differential expression of ompA, ompB, pyk, nlpD and Cpn0585 genes between normal and interferon-gammatreated cultures of Chlamydia pneumoniae, Microb.
Pneumoniae EB the lipopolysaccharide molecule carrying the common, genus-specific LPS epitope, is present. (3,4) The chlamydial major outer membrane protein MOMP, which is the major GUNNA CHRISTIANSEN and SVEND BIRKELUND ogy and Immunology, University of Aarhus, Denmark. nostics ApS, Science Park, Aarhus, Denmark. 29 Department of Medical MicrobiolBRIAN VANDAHL Loke Diag- G. CHRISTIANSEN et al. 30 constituent of the Chlamydia trachomatis surface, has a conformational epitope on MOMP trimers present at the surface, (4) but a family of polymorphic proteins (Pmps) are the major constituents of the C.