Cholestatic Liver Disease (Clinical Gastroenterology) by Keith D. Lindor, Jayant A. Talwalkar

By Keith D. Lindor, Jayant A. Talwalkar

During the last 20 years, there was a gradual elevate in wisdom linked to the scientific manifestations of cholestatic liver illness. according to those medical occasions, this publication offers worthy and well timed info at the ever-expanding topic of cholestatic liver sickness. It provides clinical updates from top specialists which relate to the scientific review and administration of cholestatic liver problems.

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EL vy C and iL ndor D K . Management of osteoporosis, fat-soluble vitamin deficiencies, and hyperlipidemia in primary biliary cirrhosis. Clin iL ver Dis 2003; 7: 901-910. 88. Chamouard P, Walter P, Baumann R, and Poupon R. Prolonged cholestasis associated with short-term use of celecoxib. Gastroenterol Clin Bioi 2005; 29: 1286-1288. 89. Tobon GJ, Canas C, aJ ller n, Restrepo C J , and Anaya 1M. Serious liver disease induced by infliximab. Clin Rheumatol 2006. 90. Schreiber AJ and Simon R F . Estrogen-induced cho1estasis: clues to pathogenesis and treatment.

55. Brown SJ and Desmond pv. Hepatotoxicity of antimicrobial agents. Semin Liver Dis 2002; 22: 157- 1 67. 56. L Fulminant liver failure and pancreatitis associated with the use of sulfarnethoxazole-trimethoprim. Am J Gastroenterol 1989; 84: 1577-1579. 57. Kowdley V K , Keeffe EB, and Fawaz KA. Prolonged cholestasis due to trimethoprim-sulfarnethoxazole. Gastroenterology 1992; 102: 214 8 - 2 150. 58. Van Steenbergen W, Peeters P, De Bondt ,J et al. Nimesulide- i nduced acute hepatitis: evidence from six cases.

Secretin then binds to the cholangiocytes which in turn activates the CFTR and results in bicarbonate secretion into the biliary canal (12). 3. PATHOGENESIS OF DRU G - I NDU C ED CHOLESTASIS The mechanisms by which medications precipitate cholestasis are complex and incompletely understood. Most drugs are lipophilic and enter the hepatocyte through the sinusoidal membrane. Within the hepatocyte, Phase I reactions (p450 system) and Phase II reactions (conjugation) occur in order to metabolize, detoxify, and facilitate the excretion of the medications.

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