Combating the Threat of Pandemic Influenza: Drug Discovery by Paul F. Torrence

By Paul F. Torrence

Drug discovery for influenza antivirals

Priorities for struggling with pandemic influenza comprise quick detection and id, the fast management of obtainable medicines to regard the an infection, the improvement of latest antivirals, and the improvement of vaccines. due to the fact lead-time can be required to supply a good vaccine, antivirals may function a key first defensive position in containing a deadly disease. varied antivirals, appearing via varied mechanisms, may aid remain the improvement of resistant viruses. hence, drug discovery for influenza antivirals is a crucial public health-related endeavor.

With chapters contributed by means of best overseas experts, this consultant will get readers up to the mark at the newest advances and applied sciences in various methods to drug discovery, covering:

latest antivirals, together with largely potent anti-respiratory virus agents

the advance of high-throughput screening assays

IFN resistance

the advance of nucleic acid-based antiviral drugs

Antiviral RNAi recommendations focusing on influenza virus

different promising antiviral drug discovery strategies

fighting the specter of Pandemic Influenza: Drug Discovery methods consolidates the most recent details on different techniques into one entire source. it really is a useful, hands-on reference for researchers in medicinal chemistry, pharmaceutical chemistry, drug discovery, biochemistry, virology, microbiology, and public health.Content:
Chapter 1 latest Influenza Antivirals: Their Mechanisms of motion and capability within the Face of Avian Influenza (pages 1–37): Erik De Clercq
Chapter 2 improvement of High?Throughput Screening Assays for Influenza (pages 38–72): Diana L. Noah, E. Lucile White and James W. Noah
Chapter three Mechanisms of IFN Resistance by means of Influenza Virus (pages 73–97): Heather J. Ezelle and Bret A. Hassel
Chapter four widely powerful Anti?Respiratory Virus brokers (pages 98–125): Shiro Shigeta
Chapter five present prestige on improvement of Nucleic Acid?Based Antiviral medicinal drugs opposed to Influenza Virus an infection (pages 126–147): Jonathan P. Wong, Mary E. Christopher, Murray Cairns, L.?Q. sunlight, Roderic M. ok. Dale and Andres M. Salazar
Chapter 6 Antiviral RNA Interference ideas concentrating on Influenza Virus and different respiration Viruses (pages 148–165): Joost Haasnoot and Ben Berkhout
Chapter 7 Promising Antiviral Glyco?Molecules from an fit to be eaten Alga (pages 166–182): Toshimitsu Hayashi, Kyoko Hayashi, Kenji Kanekiyo, Yuko Ohta, Jung?Bum Lee, Minoru Hashimoto and Takahisa Nakano
Chapter eight Rational layout of an Anti?Adhesion Drug for Influenza (pages 183–208): Nicolai V. Bovin and Alexandra S. Gambaryan
Chapter nine figuring out Influenza Neuraminidase Inhibitors utilizing Quantitative Structure–Activity dating (QSAR) versions (pages 209–225): Rajeshwar P. Verma and Corwin Hansch
Chapter 10 Peptide Inhibitors concentrating on Virus?Cell Fusion in school I Enveloped Viruses (pages 226–246): George F. Gao
Chapter eleven Novel Influenza Therapeutics (pages 247–264): Laura M. Aschenbrenner, Nicole Pelletier, Mang Yu and Fang Fang

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Clin. Infect. Dis. 2006, 43, 439–444. De Clercq, E. Strategies in the design of antiviral drugs. Nature Rev. Drug Discov. 2002, 1, 13–25. Russell, R. ; Haire, L. ; Stevens, D. ; Collins, P. ; Lin, Y. ; Blackburn, G. ; Hay, A. ; Gamblin, S. ; Skehel, J. J. The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design. Nature 2006, 443, 45–49. Luo, M. Antiviral drugs fit for a purpose. Nature 2006, 443, 37–38. McKimm-Breschkin, J. L. Resistance of influenza viruses to neuraminidase inhibitors—A review.

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