Comprehensive Virology: Vol. 16: Virus-Host Interactions: by C. Howe, J. E. Coward, T. W. Fenger (auth.), Hein

By C. Howe, J. E. Coward, T. W. Fenger (auth.), Hein Fraenkael-Conrat, Robert R. Wagner (eds.)

The time turns out ripe for a severe compendium of that section of the organic universe we name viruses. Virology, as a technology, having handed just recently via its descriptive section of naming and num­ bering, has most likely reached that level at which quite few new­ really new-viruses might be stumbled on. prompted by way of the highbrow probes and strategies of molecular biology, genetics, biochemical cytology, and excessive solution microscopy and spectroscopy, the sphere has skilled a real info explosion. Few critical makes an attempt were made to chronicle those occasions. This entire sequence, with the intention to include a few 6000 pages in a complete of approximately 18 volumes, represents a dedication through a wide workforce of lively investigators to research, digest, and expostulate at the nice mass of information in relation to viruses, a lot of that's now amorphous and disjointed, and scattered all through a large literature. during this manner, we are hoping to put the complete box in viewpoint, and to advance an invalua­ ble reference and sourcebook for researchers and scholars in any respect degrees. This sequence is designed as a continuum that may be entered anyplace, yet which additionally offers a logical development of constructing proof and built-in concepts.

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Additional resources for Comprehensive Virology: Vol. 16: Virus-Host Interactions: Viral Invasion, Persistence, and Disease

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From studies of SFV, it appears that envelope glycoproteins constituting the viral spikes mediate attachment to erythrocytes and to susceptible cells. Other than providing a hydrophilic environment for Viral Invasion 47 the viral particle, viral NANA residues are not involved in viral attachment or antigenicity, which is probably mediated by the envelope polypeptide(s) (Kennedy, 1974). Accordingly, removal of the spikes and hence all of the polypeptide portion of the viral envelope reduced infectivity, hemagglutination, and reactivity with antiviral antibody, and left viral cores intact.

1974) in which the sialic acid is exclusively N-glycolylneuraminic acid. Virus could be attached to equine erythrocytes which had been pretreated with concanavalin A (con A), a lectin which also reacts with the surface of Sendai virions. Under these circumstances hemolysis occurred due to the direct action of the virions attached to the cells through the bifunctional lectin. Influenza virus, which does not agglutinate equine erythrocytes, likewise attached to con A treated cells but did not show any signs of lysis.

4. Murine A9 cells infected with minute virus of mice. (a) Stages in viral uptake into coated vesicles by invagination (right and left) and formation of "autonomous" coated vesicles (center). Clusters of virions are seen between the plasma membrane surface and the edge of the filopodium . (b) A filopodium bearing a patch of virions is folded into the cytoplasm forming a channel which contains two viral particles. Courtesy P. Linser and R. W. Armentrout. Bar = 200 nm. Viral Invasion 19 tinal epithelial cells.

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