Cytotoxic T-Lymphocytes in Human Viral and Malaria by M. B. A. Oldstone (auth.), Michael B. A. Oldstone (eds.)

By M. B. A. Oldstone (auth.), Michael B. A. Oldstone (eds.)

Cytotoxic T lymphocytes (CTL) keep watch over a number of viral infections in animals according to deletion and reconstitution experiments with CTL clones and use of CD8 genetically poor (knock-out) mice. during this quantity, information for the function that CTL play in human infectious illnesses is gifted. As such, this represents the 1st quantity during which such details from a number of diversified viral and protozoan infections is introduced together.

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6025 2 2 0 CMV 2 0 Mock Allogeneic 639 1409 2099 4 weeks post #4 Bone marrow donor 42664 1413 861 560 CMVAg 145801 12376 11255 9951 PHA 131 9 408 142 179 Control 20796 1005 493 143 CMVAg Patient no. 6131 445524 56590 41976 22882 PHA 1 502 201 121 466 Control 9624 292 141 721 CMVAg Patient no. 6025 160964 5499 4511 4964 PHA CD4 + CMV-specific Th responses of peripheral blood lymphocytes (PBl) obtained from recipients 0,2, and 4 weeks after completion ofthe fourth (#4) T cell infusion were evaluated in a 96-h proliferation assay.

Because all Mamu-A '01-positive animals appear to generate a CTL response to this epitope, a variety of immunization strategies are presently being evaluated in Mamu-A '01 animals. Although the identification of HIV-1 gag CTL epitopes is likely to be incomplete, several general themes have emerged. The gag-specific response in HIV-1 infected humans appears to be remarkably heterogeneous. Multiple epitopes have been identified, and as many as five gag CTL epitopes have been shown to be recognized by a single individual (JOHNSON et al.

35 . . . . . . . . . . .. .. 39 39 45 47 . . . . . CTL . . . . . . . . . . . . .. .. 51 52 52 54 55 Conclusions......................................... 56 References . . . . . . . . . . . . . . . . . . . . . . 57 . . . . . . . . . . . Virus Type . . . . . 1 . . . . . . . . . . . Replication . . . . . . . by . 1 Introduction Following the identification of the human immunodeficiency virus type 1 (HIV-1) as the etiologic agent of acquired immunodeficiency syndrome (AI DS; BARRE-SINOUSSI et al.

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