Dendritic Cells: Biophysics, Tumor Microenvironment and by Zhu Zeng, Xiaofeng Xu, Dan Chen

By Zhu Zeng, Xiaofeng Xu, Dan Chen

In this e-book, the authors speak about the biophysical features of Dendritic cells (DCs) at numerous differentiation phases and in tumor microenvironments intimately. one of those chinese language conventional herb, which could enhance the biophysical and microrheological homes of DCs, can also be brought. DCs are effective and really expert antigen-presenting cells that play an important function in starting up and amplifying either the innate and adaptive immune responses. The biophysical and microrheological features of DCs are vital for his or her motility and basic immune functionality. In tumor microenvironments, the motility and immune services of DCs are impaired, however the mechanisms are mostly unknown. This ebook deals researchers a entire and deep perception into the biophysical features of DCs and will additionally aid to enhance the potency of anti-tumor treatment in response to DCs.

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1 The deformation of DCs under SMMC-7721 cell microenvironment as measured by micropipette aspiration. The length in the micropipette, L(t), is a function of time (cited from Cell Biochem Biophys. 2012;62(1):193–201. P196) 58 5 Effects of Traditional Chinese Medicine … Fig. 2 Cells that had penetrated through the chamber were counted using hemocytometer. 001. 005 (cited from Cell Biochem Biophys. 2012;62(1):193–201. P196) SMMC + GSPP conditioned medium became better than that of SMMC, even though it was still less than that of control cells.

2003;145(1–2):55–67. 16. Shurin GV, et al. Neuroblastoma-derived gangliosides inhibit dendritic cell generation and function. Cancer Res. 2001;61(1):363–9. 17. Peguet-Navarro J, et al. Gangliosides from human melanoma tumors impair dendritic cell differentiation from monocytes and induce their apoptosis. J Immunol. 2003;170(7):3488–94. 18. Kalinski P, et al. IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells.

1 The deformation of DCs under SMMC-7721 cell microenvironment as measured by micropipette aspiration. The length in the micropipette, L(t), is a function of time (cited from Cell Biochem Biophys. 2012;62(1):193–201. P196) 58 5 Effects of Traditional Chinese Medicine … Fig. 2 Cells that had penetrated through the chamber were counted using hemocytometer. 001. 005 (cited from Cell Biochem Biophys. 2012;62(1):193–201. P196) SMMC + GSPP conditioned medium became better than that of SMMC, even though it was still less than that of control cells.

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